Vidanga, The Therapeutic Agent for Osteoporosis, Diabetic and Cancer

Vidanga, or known botanically as Embelia ribes Burm., has been used as Ayurvedic herbs to treat fever, inflammatory diseases, and gastrointestinal ailments for thousands of years. Vidanga was first described by Nicolaas Laurens Burman, a Dutch botanist, in 1768.

Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone), an active compound derived from vidanga, has been shown to possess antitumor, anti-cancer, anti-diabetic, anti-inflammatory, analgesic, antioxidant, antihyperglycaemic, anthelmintic (drugs that expel parasitic worms from the body), antifungal, anticonvulsant (antiepileptic drugs), and cardioprotective properties.

The dried fruits of vidanga are mostly used as folk medicine by the Indian people, rather than its roots or its leaves. Vidanga is used to treat bronchitis, skin diseases, flatulence, migraine, cough, colic, constipation, and asthma. Vidanga is also useful for stamina booster and as an oral contraceptive. Due to its contraceptive effect, pregnant women are not allowed to take vidanga herb.

The Scientific Studies

Study had indicated that embelin is a novel nuclear factor-kappaB (NF-kappaB) blocker and potential suppressor of tumorigenesis. It is NF-kappaB which regulates several genes associated with inflammation, proliferation, carcinogenesis, and apoptosis. (Ahn KS, et al. 2007)

40 days of orally feeding aqueous vidanga extract, to streptozotocin induced diabetic rats, had produced significant decrease in heart rate, systolic blood pressure, blood glucose, blood glycosylated hemoglobin, serum lactate dehydrogenase, creatine kinase and the levels of pancreatic lipid peroxides.

The extract also significantly increased the levels of pancreatic superoxide dismutase, catalase and in blood glutathione levels. The study suggested that the aqueous vidanga extract had managed to exhibit a significant blood glucose, blood pressure lowering potential, and to enhance endogenous antioxidant defense against free radicals, which produced under hyperglycaemic conditions. (Bhandari U, et al. 2008)

Most cancer patients died not just because of the tumor in the primary organ, but because it has spread to other organs. Cancers, such as breast, myeloma, and prostate cancer, frequently metastasize (the spread of a cancer from one organ to another organ) to the bone.

NF-kappaB is also known as a major mediator of bone loss, which associated with cancer and other chronic inflammatory diseases. Study indicated that embelin had shown as an inhibitor of NF-kappaB and had great potential as a therapeutic agent for osteoporosis and cancer-linked bone loss. (Reuter S, et al. 2010)

Embelin had shown to reduce body weight gain, blood glucose, and plasma insulin, in the study using diabetic rats. The study suggested that embelin can be used in the prevention, and treatment of type 2 diabetes mellitus, caused due to obesity. (Gandhi GR, et al. 2013) Other study also suggested, that embelin can be used as a potential therapeutic candidate, for the prevention and treatment of prostate cancer. (Kim SW, et al. 2013)

Two vidanga products that are sold by Bazaar of India on Amazon.com:

Vidanga Herb Powder Wildcrafted	Vidanga - Embelia ribes, 120 vegicaps

Punarnava, The Anti-cancer and Anti-diabetic Weeds

Punarnava, or known as Boerhaavia diffusa Linn. has a long history of use in Ayurvedic herbal medicine, for the treatment of cancer, jaundice, dyspepsia, inflammation, enlargement of spleen, abdominal pain and as an anti-stress agent. Punarnava grow as weeds, and their origin have not been determined, because the plants are widespread in many places around the world.

Punarnava have so many common names, such as, erva toustao, hog weed, pig weed, atikamaamidi, djambo, etiponia, thazhuthama, thikri, katkatud, mamauri, ndandalida, oulouni niabo, touri-touri, punerva, purnoi, ghetuli, mahenshi, santi, spiderling, tellaaku, tshrana, biskhapra, and etc. But, according to Ayurveda, the Indian people had been used the roots, leaves and seeds of punarnava as folk medicine.

Herbal medications based on the extract of punarnava roots are also sold in several online Ayurvedic shops. Just like what I have found here on Amazon.com.

Banyan Botanicals Organic Punarnava Powder

Also a beauty product which contains the extract of punarnava.

VLCC Punarnava Astringent 100ml

The Scientific Studies on Anti-cancer and Anti-diabetic Properties of Punarnava

Anti-cancer

Punarnavine, an alkaloid derived from Boerhaavia diffusa, is believed to be an anti-cancer agent. The study has indicated that punarnavine could enhance the immune response, and inhibit the metastatic progression of B16F-10 melanoma cells in mice. (Manu KA, et al. 2007) Moreover, the extract from the whole plant of punarnava also possess radioprotective effect against gamma radiation induced damage in mice. (Manu KA, et al. 2007)

Boeravinones, compounds isolated from the roots of punarnava, have been found potentially to inhibit the drug efflux activity of BCRP (breast cancer resistance protein), a multidrug transporter responsible for cancer cell resistance to chemotherapy. (Ahmed-Belkacem A, et al. 2007) Punarnava show antiproliferative and antiestrogenic properties against MCF-7 breast cancer cell lines, in which are potential in the treatment of breast cancer. (Sreeja S, et al. 2009)

Anti-diabetic

When compared to glibenclamide (anti-diabetic drug), the aqueous solution of punarnava leaf extract is shown more prominent result. A significant decrease in blood glucose and significant increase in plasma insulin levels.

The study is also shown a significant reduction of glycosylated haemoglobin and an increase the total of haemoglobin level, in normal and alloxan induced diabetic rats treated with punarnava leaf extract. (Pari L, et al. 2004) Another study to demonstrate the antihyperglycaemic and renoprotective effect of punarnava in experimental diabetic rats, had shown better result when compared to the treatment using metformin (hypoglycaemic drug). (Singh PK, et al. 2011)